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Zanaflex (Tizanidine Hydrochloride)
Zanaflex is a muscle relaxant that is used to treat muscle spasms and increased muscle tone associated with spesticity. Zanaflex?works by blocking nerve impulses.
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Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Uses
Zanaflex is used to treat muscle spasms.
How to Use
Take as directed. Your dosage will probably need to be adjusted by your doctor initially to achieve satisfactory results. Follow directions exactly.
Side Effects
Nausea, drowsiness, dizziness, constipation, unusual weakness or dry mouth might occur. If these continue or are bothersome, notify your doctor. To minimize dizziness, stand up slowly when arising from a sitting or lying position. Notify your doctor if you develop: yellowing skin or eyes, stomach pain, vomiting, hallucinations. Very unlikely but report: vision or hearing changes, urinary frequency or burning, slow or irregular heartbeat, black stool. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
Before taking this drug, tell your doctor if you have: any allergies, low blood pressure, liver or heart disease, kidney disease, eye disease. Limit the use of alcohol as alcohol may intensify the dizziness and drowsiness effects of this drug. Use caution when driving or operating machinery or when alertness is required. Zanaflex should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into human milk. Consult your doctor before breast-feeding. Caution is advised when this drug is used in the elderly.
Drug Interactions
Tell your doctor of all prescription and nonprescription zanaflexas you may take, especially of: blood pressure drugs (e.g., water pills, clonidine, methyldopa, guanabenz, guanfacine), MAO inhibitors (e.g., linezolid, furazolidone, phenelzine, selegiline), sleep medicines, sedatives (e.g., diazepam), tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine, morphine), barbiturates (e.g., phenobarbital), certain antihistamines (e.g., diphenhydramine), other muscle relaxants (e.g., cyclobenzaprine), certain antidepressants (e.g., imipramine, amitriptyline, trazodone), phenothiazine psychiatric drugs (e.g., chlorpromazine), birth control pills. Do not start or stop any medicine without doctor or pharmacist approval.
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include trouble breathing or unconsciousness.
Notes
Your doctor may monitor liver tests during treatment. Do not share Zanaflex with others.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Storage
Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.
Directions Take exactly as directed. The danger of side effects increases with the size of the dose. Doses should be taken only as needed. Allow 6 to 8 hours between doses. Take no more than 3 a day. Never double the dose.
Patient information May cause nausea, drowsiness, dizziness, constipation, unusual weakness or dry mouth. If these continue or are bothersome, notify your doctor. To minimize dizziness, stand up slowly when arising from a sitting or lying position. Notify your doctor if you develop: yellowing skin or eyes, stomach pain, vomiting, hallucinations. Very unlikely but report: vision or hearing changes, urinary frequency or burning, slow or irregular heartbeat, black stool. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions Before taking this drug, tell your doctor if you have: any allergies, low blood pressure, liver or heart disease, kidney disease, eye disease. Limit the use of alcohol as alcohol may intensify the dizziness and drowsiness effects of this drug. Use caution when driving or operating machinery or when alertness is required. This zanaflexa should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into human milk. Consult your doctor before breast-feeding. Caution is advised when this drug is used in the elderly.
Drug interactions Tell your doctor of all prescription and nonprescription zanaflexas you may take, especially blood pressure drugs (e.g., water pills, clonidine, methyldopa, guanabenz, guanfacine), MAO inhibitors (e.g., linezolid, furazolidone, phenelzine, selegiline), sleep medicines, sedatives (e.g., diazepam), tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine, morphine), barbiturates (e.g., phenobarbital), certain antihistamines (e.g., diphenhydramine), other muscle relaxants (e.g., cyclobenzaprine), certain antidepressants (e.g., imipramine, amitriptyline, trazodone), phenothiazine psychiatric drugs (e.g., chlorpromazine), birth control pills. Do not start or stop any medicine without doctor or pharmacist approval.
IMPORTANT
NOTE: The following information is intended
to supplement, not substitute for, the expertise
and judgment of your physician, pharmacist or
other healthcare professional. It should not
be construed to indicate that use of the drug
is safe, appropriate, or effective for you.
Consult your healthcare professional before
using this drug.
TIZANIDINE - ORAL
(tize-AN-ih-deen)
COMMON BRAND NAME(S):
Zanaflex
USES: This
zanaflexa is used to treat muscle spasms.
HOW TO USE:
Take as directed. Your dosage will probably
need to be adjusted by your doctor initially
to achieve satisfactory results. Follow directions
exactly.
SIDE EFFECTS:
Nausea, drowsiness, dizziness, constipation,
unusual weakness or dry mouth might occur. If
these continue or are bothersome, notify your
doctor. To minimize dizziness, stand up slowly
when arising from a sitting or lying position.
Notify your doctor if you develop: yellowing
skin or eyes, stomach pain, vomiting, hallucinations.
Very unlikely but report: vision or hearing
changes, urinary frequency or burning, slow
or irregular heartbeat, black stool. An allergic
reaction to this drug is unlikely, but seek
immediate medical attention if it occurs. Symptoms
of an allergic reaction include rash, itching,
dizziness, trouble breathing. If you notice
other effects not listed above, contact your
doctor or pharmacist.
PRECAUTIONS : Before
taking this drug, tell your doctor if you have:
any allergies, low blood pressure, liver or
heart disease, kidney disease, eye disease.
Limit the use of alcohol as alcohol may intensify
the dizziness and drowsiness effects of this
drug. Use caution when driving or operating
machinery or when alertness is required. This
zanaflexa should be used only when clearly
needed during pregnancy. Discuss the risks and
benefits with your doctor. It is not known whether
this drug is excreted into human milk. Consult
your doctor before breast-feeding. Caution is
advised when this drug is used in the elderly.
DRUG INTERACTIONS:
Tell your doctor of all prescription and nonprescription
zanaflexas you may take, especially of: blood
pressure drugs (e.g., water pills, clonidine,
methyldopa, guanabenz, guanfacine), MAO inhibitors
(e.g., linezolid, furazolidone, phenelzine,
selegiline), sleep medicines, sedatives (e.g.,
diazepam), tranquilizers, anti-anxiety drugs,
narcotic pain relievers (e.g., codeine, morphine),
barbiturates (e.g., phenobarbital), certain
antihistamines (e.g., diphenhydramine), other
muscle relaxants (e.g., cyclobenzaprine), certain
antidepressants (e.g., imipramine, amitriptyline,
trazodone), phenothiazine psychiatric drugs
(e.g., chlorpromazine), birth control pills.
Do not start or stop any medicine without doctor
or pharmacist approval.
OVERDOSE: If OVERDOSEis suspected, contact your local poison
control center or emergency room immediately.
Symptoms If OVERDOSEmay include trouble breathing
or unconsciousness.
NOTES : Your
doctor may monitor liver tests during treatment.
Do not share this zanaflexa with others.
MISSED DOSE : If you miss a dose, take
it as soon as you remember. If it is near the
time of the next dose, skip the MISSED DOSEand resume your usual dosing schedule. Do not
"double-up" the dose to catch up.
STORAGE : Store
at room temperature between 59 and 86 degrees
F (15-30 degrees C) away from light and moisture.
ZANAFLEX (tizanidine hydrochloride) is a centrally acting a2-adrenergic
agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline
powder, odorless or with a faint characteristic odor. Tizanidine is slightly
soluble in water and methanol; solubility in water decreases as the pH
increases. Its chemical name is
5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiodiazole hydrochloride.
Tizanidine's molecular formula is C9H8ClN5S.HCl, its molecular weight is 290.2
and its structural formula is:

Zanaflex is supplied as 2 and 4 mg tablets for oral administration. Zanaflex
tablets are composed of the active ingredient, tizanidine hydrochloride (2.288
mg equivalent to 2 mg tizanidine base and 4.576 mg equivalent to 4 mg tizanidine
base), and the inactive ingredients, silicon dioxide colloidal, stearic acid,
microcrystalline cellulose and anhydrous lactose.
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